Why isn't B12 in my GLP-1 anymore?

If you used to receive B12 in your GLP-1 vial and don't see it anymore, here's what changed: our compounding pharmacies have moved away from adding B12 to compounded GLP-1s. Most formulations now include vitamin B6, and some use glycine (a basic amino acid used as a stabiliser) instead.

What you're most likely receiving

• Standard formulation with B6 — what most patients get. The solution looks clear to slightly yellow, which is normal.
• Glycine-based or additive-free — if you flagged a B-vitamin allergy or sensitivity at intake, your order is routed automatically to one of these. These look clear or near-colourless. (See "Which tirzepatide formulation am I on?")

This applies to both tirzepatide and semaglutide — the shift away from B12 wasn't specific to one medication.

If you want B12

• You can add a MIC+B12 shot as a separate treatment — it's a dedicated B12 (with methionine, inositol, and choline) injection. (See "What is MIC+B12 and how does it work?")
• An over-the-counter B12 supplement from your pharmacy is also an option.

Good to know

• B6 is included by default unless you flagged a B-vitamin allergy, in which case you'll receive a B6-free option instead.
• Not having B12 in your GLP-1 vial doesn't reduce how well your treatment works — the B vitamin was an add-in, not the active medication.

Not sure which formulation you have? Check your vial label or message us and we'll confirm.