What is Semax and how does it work?

Semax is a lab-made peptide, taken as a nasal spray, that is used to support focus, memory and mental clarity. Some people use it for brain fog.

It is based on a small piece of ACTH, a hormone your body makes naturally. Studies suggest it raises BDNF, a protein that supports brain cells. Most of that research comes from outside the US and it is limited, so we will not promise more than the evidence shows. Results are not guaranteed and they vary from person to person.

When will I notice something?

There is no established timeline for Semax, and we would rather tell you that than guess. Your provider will talk through what you can realistically expect.

How is it taken?

One spray in each nostril once a day. There are no needles. Your dose and how to use it are in "How do I store, handle, and use Semax nasal spray?"

Who should not take Semax

Semax is not right for you if you are pregnant, breastfeeding, or trying to conceive, if you have active cancer or are in cancer treatment, if you have seizures or a seizure disorder, or if you have psychosis or a serious mental health condition. It is also not prescribed with active liver disease or severe kidney disease, with an allergy to peptide medicines, or under the age of 18.

Tell your provider about every medication you take, and especially a benzodiazepine, an SSRI or an SNRI. If you are not sure whether one of yours is on that list, include it anyway and your provider will know.

Is Semax FDA approved?

No. Semax is approved in Russia, but it is not FDA approved in the US. What Belle prescribes is a compounded medication, and compounded medications are not reviewed by the FDA for safety, effectiveness or quality. Its long-term safety in people isn't established. It is available by prescription only, after a licensed provider reviews your health history.

Is it the same as the Semax sold online?

No. Most Semax sold online is labeled for research use, not for people, with no prescription and no verified purity or dose. Belle's Semax is prescribed by a US-licensed provider and filled by a US-licensed pharmacy.

Can I take it with my other Belle treatments?

That depends on what you take, so it is your provider's call. They review Semax alongside everything else you are on, including a GLP-1 or another Belle treatment, before prescribing it.

Is it available in my state?

Semax is not available in every state yet. The current list is in "Peptide plans, shipments, and billing: how it works".

What about side effects?

See "Semax side effects and what's normal".