Compounded GLP-1 (Semaglutide) Safety Information

Do Not Use If You:

Have a personal or family history of medullary thyroid carcinoma (MTC)

Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Are pregnant or planning to become pregnant

Are breastfeeding

Have had a serious allergic reaction to semaglutide or any of its ingredients

Before Using Compounded GLP-1

Tell your healthcare provider about your full medical history, including if you have:

Kidney, liver, or pancreas problems

A history of pancreatitis or gallbladder disease

Severe gastrointestinal disease

A history of diabetic retinopathy

Depression, suicidal thoughts, or behavior changes

Discuss all prescription and non-prescription medications, vitamins, and supplements you take, especially:

Insulin or insulin secretagogues (e.g., sulfonylureas)

Thyroid hormone medication

Medications with a narrow therapeutic range (e.g., warfarin)

Pregnancy, Breastfeeding & Contraception

Do not use if you are pregnant, planning to become pregnant, or breastfeeding.

Stop treatment at least 2 months before trying to conceive.

Use effective contraception while on treatment.

This medication may cause fetal harm.

Serious Warnings: Call Your Doctor Immediately If You Experience:

Thyroid C-cell tumor symptoms (see Black Box Warning above)

Pancreatitis: severe abdominal or back pain that does not go away, with or without vomiting

Gallbladder disease: pain in the upper right stomach, fever, yellowing of skin or eyes, nausea or vomiting

Kidney problems: reduced urination, swelling, fatigue, especially if dehydrated from nausea, vomiting, or diarrhea

Diabetic retinopathy changes: sudden vision changes

Serious allergic reaction: swelling of face, lips, tongue, or throat; difficulty breathing or swallowing; rash, itching, fainting, dizziness, or rapid heartbeat

Hypoglycemia (especially if also taking insulin or sulfonylureas): dizziness, confusion, sweating, rapid heartbeat, shakiness, headache

Worsening depression or suicidal thoughts

If any of these occur, stop treatment and seek immediate medical attention.

Common Side Effects

Some people experience no side effects. The most common include:

Nausea, vomiting, diarrhea, constipation, abdominal pain

Headache, dizziness, fatigue

Indigestion, upset stomach, acid reflux

Decreased appetite

Injection site reactions

Side effects are usually mild to moderate and tend to decrease over time. Contact your provider if symptoms persist or worsen.

Drug Interactions

Compounded semaglutide slows gastric emptying, which may impact the absorption of oral medications.

Dose adjustments may be required for insulin, sulfonylureas, thyroid hormone, and medications with a narrow therapeutic index.

Monitor closely if on warfarin or other blood thinners.

Important Note on Compounded Medications

Compounded semaglutide is prepared by a licensed compounding pharmacy and is not evaluated by the FDA for safety or effectiveness. It is not equivalent to FDA-approved semaglutide products such as Wegovy® or Ozempic®.

Emergency Information

In case of a medical emergency, call 911 or go to the nearest emergency room.

To report side effects, contact the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.