A Belle member asked
Nervous about NAD+
25 replies · 💉 GLP-1 and peptide education · Aug 2026
I ordered NAD+ that will arrive next week. I ordered it because it was recommended for irritability and anxiety. I have learned recently that it can be difficult to inject because it causes a strange feeling. Are the injections weekly? Also, I’m concerned about sleep. I tend to wake up in the middle of the night trying to solve problems in the day. I will definitely inject in the mornings but can it cause insomnia? I do have melatonin. Just anything you tell me to educate me would be great.
- Belle member
I haven't heard any of this, I have been on nad+ for 2 months and have not had any of these reactions
- Belle member
@member That’s comforting. Are you noticing improvements in well-being?
- Belle member
I have been on NAD+ for two months. I also suffer from anxiety/depression. It doesn’t make me feel any worse. It also does not affect my sleep (I take melatonin too). The injections don’t really feel any different than the GLP1 I take. Maybe a slight sting, nothing to worry about. I started with 80mg once a week and gradually increased to 80mg 3x a week. Hope this helps. Good Luck
- Belle member
@member the reason I am taking is for fatigue 😩, like with most it takes some time to build up in your system, at first I wasn't feeling much difference ( or do I thought) I forgot to take mine one morning and choose to take that night, ummm HUGE mistake I was up all night, lol, so in summary it has improved my fatigue
- Belle member
I have been on it for 2 months as well . No reactions so far not really sure I’m feeling anything off of it . I’m still in the let’s see trial of this med I feel like .
- Belle member
@member Thank you. This is very helpful. He’s starting me on 20mg. That should be pretty safe.
- Belle member
@member williams Makes sense. I look forward to seeing if it helps the irritability. Something has felt a bit off balance since taking Tirz. Thank you.
- Belle member
I’ve been on it for a good while now (like over 4 months) and never had any of this. I have a history of anxiety (like I’m prone to it but it is currently not showing up) as well as being prone to insomnia for years and the NAD+ does not cause any of this for me. Also doesn’t feel weird at all when injecting it, it is very easy to inject. You could get a flushing feeling from it where you feel warm and jittery possibly but that would only last maybe 10 mins… but for me even on the max dose you work up to per the instructions (80 units) any effect like that is either not noticeable or super mild depending on the day. You take it a few times a week. It is really great for energy and I think it improves mood. There’s nothing to worry about and once you get your levels up I think you’ll be happy with the improvements it gives you.
- Belle member
@member Thank you so much. Should be good. 👍🏼 Feel better about it.
- Belle member
@member for the rumination about problems when you wake up during the night.. vitamin b1 deficiency causes that. If I have that I take some benfotiamine. But if you aren’t already it also helps to eat small snacks during the day so you eat a total of 5 times to prevent waking up because it is reassuring to the body.
- Belle member
@member Great advice. Thank you 😊
- Belle member
Ne company, forget which one but makes a nasal spray so there goes away the fear of shot hurting. I used it for 3 months. Decided budget wise it wasn’t a fit for my necessities.
- Belle member
I really think it differs from person to person. I did NAD but it did cause me insomnia. I had soooo much energy though. I did end up stopping because of the insomnia and I’ve been fine since! MIC B12 tends to be the better fit for me personally.
- Belle member
@member you for sharing. I probably should have ordered one month vs three. Too late now. Fingers crossed 🤞
- Belle member
@member hope that you have better results. I’ve heard that insomnia is more likely to happen in younger folks. I’m 22 so it makes sense!
- Belle member
@member’m older so it might be perfect
- Belle member
@member’m thinking it will be amazing for you!
- Belle member
I have been using it for about 6 weeks. I’ve been building up to the max dose, adding a little each time. I use it twice a week. The only thing I’ve noticed is a burning sensation after injecting. My sleep was lousy before and is still lousy so not impact there. I tell myself that it is helping my energy level but I don’t know for sure. I’ll see how I feel after the next refill.
- Belle member
I definitely try to pin NAD earlier in the day because it is activating for me, but as long as I do that then I don’t notice any disturbances in sleep. The Sermorelin definitely helps me sleeping like a little baby though.
- Belle member
@member Nikki, do the two go together well? NAD+ and Sermorelin? I’m talking with Dr Taylor next week as well.
- Belle member
I like them!! The Sermorelin increases your natural HGH production so it tends to help with sleep. I find it really helps me in the gym and with recovery.
- Belle member
@member understand. But can they be taken together?
- Belle member
@member oh yes I take them both together!
- Belle member
I have been taking NAD= for months and have had no issues. No strange feelings or anything. Just get red around injection site for a little bit.
- Belle member
@member Yes, I just started yesterday. Feels good actually.
Shared by Belle members about their own experience. Not medical advice: ask your care team before changing anything.