Important Safety Information

Do Not Use If You:

• Have a personal or family history of medullary thyroid carcinoma (MTC)
• Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Are pregnant or planning to become pregnant
• Are breastfeeding
• Have had a serious allergic reaction to semaglutide or any of its ingredients

Before Using Compounded GLP-1

Tell your healthcare provider about your full medical history, including if you have:

• Kidney, liver, or pancreas problems
• A history of pancreatitis or gallbladder disease
• Severe gastrointestinal disease
• A history of diabetic retinopathy
• Depression, suicidal thoughts, or behavior changes

Discuss all prescription and non-prescription medications, vitamins, and supplements you take, especially:

• Insulin or insulin secretagogues (e.g., sulfonylureas)
• Thyroid hormone medication
• Medications with a narrow therapeutic range (e.g., warfarin)

Pregnancy, Breastfeeding & Contraception

• Do not use if you are pregnant, planning to become pregnant, or breastfeeding.
• Stop treatment at least 2 months before trying to conceive.
• Use effective contraception while on treatment.
• This medication may cause fetal harm.

Serious Warnings: Call Your Doctor Immediately If You Experience:

• Thyroid C-cell tumor symptoms (see Black Box Warning above)
• Pancreatitis: severe abdominal or back pain that does not go away, with or without vomiting
• Gallbladder disease: pain in the upper right stomach, fever, yellowing of skin or eyes, nausea or vomiting
• Kidney problems: reduced urination, swelling, fatigue, especially if dehydrated from nausea, vomiting, or diarrhea
• Diabetic retinopathy changes: sudden vision changes
• Serious allergic reaction: swelling of face, lips, tongue, or throat; difficulty breathing or swallowing; rash, itching, fainting, dizziness, or rapid heartbeat
• Hypoglycemia (especially if also taking insulin or sulfonylureas): dizziness, confusion, sweating, rapid heartbeat, shakiness, headache
• Worsening depression or suicidal thoughts

If any of these occur, stop treatment and seek immediate medical attention.

Common Side Effects

Some people experience no side effects. The most common include:

• Nausea, vomiting, diarrhea, constipation, abdominal pain
• Headache, dizziness, fatigue
• Indigestion, upset stomach, acid reflux
• Decreased appetite
• Injection site reactions

Side effects are usually mild to moderate and tend to decrease over time. Contact your provider if symptoms persist or worsen.

Drug Interactions

• Compounded semaglutide slows gastric emptying, which may impact the absorption of oral medications.
• Dose adjustments may be required for insulin, sulfonylureas, thyroid hormone, and medications with a narrow therapeutic index.
• Monitor closely if on warfarin or other blood thinners.

Important Note on Compounded Medications

Compounded semaglutide is prepared by a licensed compounding pharmacy and is not evaluated by the FDA for safety or effectiveness. It is not equivalent to FDA-approved semaglutide products such as Wegovy® or Ozempic®.

Emergency Information

• In case of a medical emergency, call 911 or go to the nearest emergency room.
• To report side effects, contact the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.