Copper Peptide Cream (GHK-Cu 0.5%) Safety Information

Do Not Use If You:

Are pregnant or breastfeeding

Have a copper-metabolism disorder, such as Wilson's disease or Menkes disease

Have a known allergy or sensitivity to copper or other heavy metals

Have active liver disease or kidney failure (stage 4 or 5)

Have a zinc deficiency or transfusion-dependent anemia

Are under 18

Have an active skin infection at the application site, or an active malignancy

Have had an allergic reaction to GHK-Cu or any of its ingredients

Before Using Copper Peptide Cream

Tell your provider about your full medical history, including if you have:

Any copper or heavy-metal sensitivity

Liver or kidney conditions

Low zinc levels or a history of anemia

Sensitive or reactive skin, or active breakouts at the application site

Also tell your provider about the skincare products and topical medications you use, especially strong vitamin C, retinoids, or exfoliating acids (AHAs/BHAs).

Pregnancy & Breastfeeding

Do not use if you are pregnant or breastfeeding.

If you are planning to become pregnant, talk to your provider before starting or continuing use.

Call Your Provider If You Experience:

A serious allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; widespread rash, hives, or dizziness

Significant or worsening skin irritation: persistent redness, burning, blistering, or swelling at the application site

Any reaction that does not settle when you reduce use

If you have a serious allergic reaction, stop use and seek immediate medical attention.

Common Side Effects

Some people have no side effects. The most common are mild and limited to where the cream is applied:

Skin dryness (more likely with frequent use)

Temporary redness, irritation, or itching at the application site

Your provider may suggest zinc supplementation alongside it. Contact your provider if symptoms persist or worsen.

Product Interactions

No significant systemic drug interactions are expected with topical use.

Avoid applying in the same step as strong vitamin C, retinoids, or strong exfoliating acids (AHAs/BHAs), which can reduce how well the copper peptide works or increase irritation.

Important Note on Compounded Medications

Copper Peptide Cream is prepared by a licensed compounding pharmacy and is not evaluated by the FDA for safety or effectiveness. Availability and outcomes can differ from FDA-approved products.

Emergency Information

In a medical emergency, call 911 or go to the nearest emergency room.

To report side effects, contact the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.