What is the difference between compounded semaglutide and tirzepatide?
Belle Answers · Medications · Updated Jul 9, 2026
Both are GLP-1 medications, but tirzepatide also activates a second receptor (GIP) in addition to GLP-1, which tends to produce stronger appetite reduction and greater weight loss in clinical trials. Compounded semaglutide starts at $119/month; compounded tirzepatide starts at $179/month and is Belle's most popular treatment. Your provider will recommend the right starting point based on your history and goals.
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