Split dosing or switch drugs?

I am currently at maintenance on low dose Semaglutide (responded really well on 0.35mg and have stayed on it till now). I have been at my current weight for about 3 months and not looking to lose more. I inject once a week but have GI side effects during the 1st 2 days after my shot (since the very beginning of this journey). Lately I have noticed some food noise coming back. I am considering splitting my dose every 3 1/2 days vs switching to Tirzepatide. I was going to switch to tirz a while back but chickened out because I was responding so well on a low dose of Sema. Also, sema is more affordable and I don’t want to commit to 6 months of tirz from the very beginning before knowing how well I respond. Does anyone have any experience on split dosing with Sema? Has anyone had a similar experience of food noise returning and GI side effects while on maintenance? I am due for a refill in 6 weeks so it might be a good time to make the switch.

1. Belle member

   Definitely speak with the medical team for what will be best for you. I was never able to handle semi had gi issues and the worst headache for days that I moved to triz and reached goal 6 months later. Best of luck

2. Belle member

   I found that I have experienced fewer GI side effects with Tirzepatide. I had much more heartburn and acid reflux with sema and I feel like the food noise is quieter with Tirz. But everyone is different so definitely talk to the care team. Good luck!

3. Belle member

   Send a message to the care team and they would be more than happy to chit chat about if split dosing is a good option for you and your personalized protocol! 🙂

4. Belle member

   You don't have to commit to 6 months. You can get 2 months.

5. Belle member

   I personally spent my dosage when I was at the higher dosages but now I’m in maintenance. It helped with some of the side effects and curved my appetite for a longer period period. However, speak to your provider to see if it’s a good fit for you.