Needing a higher dose for the same effect? It's not your or your metabolisms fault.

Recent data is incredibly interesting that even though women tend to respond with greater weight loss with GLP1s especially Tirzepatide, there may be an Estrogen AND genetic component to how you respond individually. Large study in Nature showed that gene receptor expression causes some people to have either larger side effects and/or higher response to GLP1s. Then theres the data that GLP1 receptors INCREASE in expression in response to high estrogen states. WHAT?! That means that you may respond more in different parts of your cycle AND if you are in a low estrogen state (perimenopause or postmenopause) you may need higher levels of GLP1 to get the same response! Anyone seeing this? I definitely have in my clinical practice.

1. Belle member

   Yes! This I have been losing very slowly, but I'm scared to increase to 15mg because what if I stall at the highest dose???? No side effects and I feel great at 11mg. I'm 52 so might be perimenopause.

2. Tiffany Bailey PA-C · Belle expert

   This is incredibly validating- considering we all know that GLP1s don’t work the same every week or every month or for every person!

3. Dr. Pat Taylor, MD · Belle expert

   @member a reasonable fear! But what if it goes great? Talk to your Belle provider about it!

4. Belle member

   @Dr. Pat Taylor, MD thank you, I did and they said to increase slowly too so pretty much confirming my fears lol

5. Belle member

   So….more estrogen, please!!! Hahaha. Just kidding, but that is very thought provoking and just another layer to think about when stalling too.

6. Dr. Pat Taylor, MD · Belle expert

   @member Absolutely why we are launching MHT, the two most impactful therapies we can offer for the perimenopausal and menopausal woman for her long term health = GLP1 and MHT.

7. Belle member

   @Dr. Pat Taylor, MD I cannot wait for this to launch!

8. Belle member

   I took a DUTCH test and my hormones are “bottomed out” what can I do? Been on Triz since end of March and started Belle in June 5mg total lost since started 7lbs I’m 55 and have been post menopause for a few years. Also took a comprehensive GI mapping test showed leaky gut but I have that under control

9. Belle member

   So should I possibly up my dose after I complete the 5mg?

10. Belle member

    @member henckel See when to titrate up in the posts below

11. Belle member

    This makes since so since I have no hormones I was put into surgical menopause 13 years ago and never put on hormones. I have been having a very hard time losing weight Tirzepatide not really working for me. Well probably because I have zero estrogen. I am on 10mg because don’t want to get to highest dose and then what, I finally got doctor to agree to estradiol patch so this will be interesting to see if it helps.

12. Belle member

    Me too can’t lose the weight did 2 DUTCH tests and below the grid on estrogen and testosterone the hormone pathways are so messed up

13. Belle member

    @Dr. Pat Taylor, MD I’m a super responder in post menopause. I’m not sure why. I am on low dose Tirzepatide moving into month 4. I am noticing a slowdown in weight loss now. Down to the last 18 lbs to go.

14. Belle member

    So I am late to this post I know @Dr. Pat Taylor, MD .. but does this mean that women who are taking estrogen would see a greater effect from their GLP1?