Storing your Medication
How to keep each medication safe and effective between doses, from the moment it arrives to your last shipment.
Belle Answers · Getting started · Updated Oct 19, 2026
Storing your medication the right way keeps it safe and working. Find your medication in the table below, follow the everyday rules, then check your medication's own notes at the bottom.
[embed](https://customer-wcwkaw4j2qxo5a1v.cloudflarestream.com/c828bce3c2d0fc05e13ea35eb2922b3a/iframe)
> 💡 The short version: Peptides and GLP-1s go in the fridge. Hormone therapy and MIC+B12 stay at room temperature in a cool, dry place. Never freeze any of it.
Quick reference
| Medication | Store it in | Good to know |
| --- | --- | --- |
| Tirzepatide | Fridge | Once opened, always keep it in the fridge |
| Semaglutide | Fridge | Once opened, always keep it in the fridge |
| MIC+B12 | Room temperature | Cool, dry place, out of sunlight. No fridge needed. |
| GHK-Cu | Fridge | Should look clear and blue |
| Glutathione | Fridge | Freezing ruins it |
| NAD+ | Fridge | Keep it upright, away from the back wall |
| Tesamorelin | Fridge | Arrives already mixed |
| Sermorelin | Fridge | Olympia vials have a cap to remove first |
| BPC-157 | Fridge | Arrives already mixed |
| MOTS-c | Fridge | Arrives already mixed |
| Estradiol valerate (injection) | Room temperature | Cool, dry place. Don't refrigerate, because cold can cause crystals. |
| Testosterone cypionate (injection) | Room temperature | Cool, dry place. Don't refrigerate, because cold can cause crystals. |
| Biest cream | Room temperature | Cool, dry place. Keep the cap on your Topi-Click or MD Click. Let it dry for at least an hour. |
| Testosterone cream | Room temperature | Cool, dry place. Keep the cap on your Topi-Click or MD Click. Let it dry for at least an hour. |
| Progesterone capsules | Room temperature | Cool, dry place, in the original bottle |
| Estradiol vaginal cream | Room temperature | Cool, dry place. Apply with your finger, not the applicator. |
When your package arrives
1. Open it as soon as it arrives. Don't leave it sitting on the porch or in the mailbox.
2. Move refrigerated medications to the fridge right away. This applies even if your package came with cold packs.
3. Keep each vial in its original packaging. The box protects it from light.
GHK-Cu, tesamorelin, BPC-157 and MOTS-c arrive already mixed and ready to use. There is nothing for you to mix or measure.
Everyday rules for refrigerated medications
- Keep your fridge at 36 to 46°F (2 to 8°C).
- Pick a middle shelf. Stay away from the back wall and the freezer vents, where it can get cold enough to freeze.
- Never freeze it. Freezing can damage the medication and make it ineffective or unsafe.
- Keep it out of the light. Leave it in its original box, away from direct sunlight.
- Put it back right after each dose. Don't leave it on the counter.
- Keep it away from heat. Never leave it in a hot car.
If a medication was left out
1. Put it back in the fridge right away.
2. Message us and tell us how long it was out.
For room-temperature medications, like hormone therapy and MIC+B12: if it got very hot or very cold (for example, left in a hot car or frozen), message us before you use it.
How long a medication can safely stay out depends on the medication and the pharmacy that filled your order, so we'll check it for you.
Before every dose, check how it looks
- Injectable medications should look clear. Don't use a vial that looks cloudy or has particles in it. Message us instead.
- Estradiol valerate and testosterone cypionate can form crystals if they get cold. Warm the vial in your hands and gently roll it until they dissolve. If they don't dissolve, don't use it. Message us instead.
- GHK-Cu is supposed to be blue. That color comes from the copper. Clear and blue is exactly right.
Notes for each medication
Find your medication below for anything specific to it.
Tirzepatide and semaglutide (weight loss)
- Keep vials in the fridge at 36 to 46°F (2 to 8°C).
- Keep them away from freezer vents, direct sunlight and hot cars.
- Put the vial back in the fridge right after each dose.
- Once a vial has been punctured, always keep it in the fridge, even if it was fine at room temperature during shipping.
- An opened vial is good for the number of weeks on your prescription.
MIC+B12 (metabolic support)
- No fridge needed. Store it in a cool, dry place out of direct sunlight.
- Keep the vial upright.
- Keep it away from light.
GHK-Cu, tesamorelin, BPC-157 and MOTS-c
- Keep it in the fridge, away from direct light. Do not freeze it.
- It arrives already mixed. There is nothing to mix or measure. Move the vials to the fridge as soon as it arrives.
- If it was left out, put it back in the fridge and message us with how long it was out.
- Don't use it if it looks cloudy or has particles in it.
- GHK-Cu only: it should look clear and blue. The blue is the copper.
Glutathione and NAD+
- Keep it in the fridge at 36 to 46°F (2 to 8°C) whenever you're not using it.
- Keep it away from the freezer, the back of the fridge, and direct light.
- Never freeze it. Freezing can damage the medication and make it ineffective or unsafe.
- NAD+ only: store the vial upright, in its original packaging when you can.
Sermorelin (growth hormone support)
- Keep it in the fridge at 36 to 46°F (2 to 8°C), away from direct light. Do not freeze it.
- It ships with cold packs. Open the package as soon as it arrives and move the medication to the fridge right away.
- If your vial came from Olympia, it has a small metal center cap you need to remove before your first dose. [Watch this video](https://www.joinbelle.com/help/articles/how-to-remove-the-metal-center-cap-on-your-olympia-vial) to see how.
Menopausal hormone therapy (estradiol, Biest, progesterone and testosterone)
Estradiol valerate and testosterone cypionate (injections)
- Store at room temperature, 68 to 77°F (20 to 25°C), in a cool, dry place. Keep the vial in its original box, away from light.
- Don't put them in the fridge. These medications are mixed in oil, and cold can form small crystals.
- If you see crystals, warm the vial in your hands and gently roll it until they dissolve. If they don't dissolve, don't use it. Message us.
- Keep it away from heat. Never leave it in a hot car.
- Use it by the date on your pharmacy label.
Biest and testosterone creams (Topi-Click or MD Click)
- Store at room temperature in a cool, dry place with the cap on.
- Keep it away from heat and direct sunlight. Don't refrigerate or freeze it.
- Keep it where children and pets can't reach it.
- Let the cream dry for at least an hour before skin-to-skin contact. This keeps the medication from transferring to partners, children and pets.
- Use it by the date on your pharmacy label.
Progesterone capsules
- Store at room temperature in a cool, dry place, out of direct sunlight.
- Keep them in the original bottle with the lid closed tightly.
- Don't keep them in the fridge.
- Use them by the date on your pharmacy label.
Estradiol vaginal cream
- Store at room temperature in a cool, dry place, out of direct sunlight, with the cap on tightly.
- Throw away the applicator that comes with it. We recommend applying the cream with your finger instead.
- Wash your hands before and after each use.
- Let the cream dry for at least an hour before skin-to-skin contact. This keeps the medication from transferring to partners, children and pets.
- Use it by the date on your pharmacy label.
> 💬 Not sure about something? Message your care team. We'd rather you ask than guess.
Education only, not medical advice.