How do I store, handle, and inject glutathione?

Keep glutathione refrigerated between 36°F and 46°F whenever it is not in use, away from the freezer and out of direct light. Never freeze it.

Freezing can degrade the medication and make it ineffective.

Before each injection

Take the vial out and let it come to room temperature for 10 to 15 minutes. Injecting cold solution can make the site more uncomfortable.

Inspect the vial every time. The solution should be clear to slightly yellow and free of particles or cloudiness. If anything looks off, contact us before using it.

Once opened

Follow the expiration guidance on your pharmacy label. Write the date you opened the vial on the label so you can track it easily.

If your vial shipped from Olympia, it has a small metal center cap that must be removed before your first dose. See "How to remove the metal center cap on your Olympia vial".

Where to inject and how to rotate

Rotate between your abdomen, outer thigh and the back of your upper arm, using a different site with each dose. Rotating prevents localized irritation, scar tissue buildup and lipodystrophy, which are changes in fat tissue that can develop from repeated injections in one spot.

A simple rotation: abdomen on Monday, thigh on Wednesday, upper arm on Friday. Alternate sides each week, left abdomen one week, right the next. This gives each area time to recover. Stay at least two inches from your navel when using the abdomen.

Technique

Clean the site with an alcohol swab and let it dry completely. Pinch a fold of skin and insert the needle straight in, at a 90-degree angle, in one quick motion. Pull back slightly on the plunger to check for blood. If you see any, withdraw and choose a new spot. Then inject slowly. Apply light pressure afterwards with a clean swab. Do not rub.

What is normal

Mild redness or minor tenderness afterwards is normal and usually settles within a day or two. If you notice significant swelling, prolonged pain, warmth or any sign of infection, contact your provider.

Can I take smaller doses more often?

The standard Belle schedule is three times a week, for example Monday, Wednesday, and Friday. Your label shows your own dose and schedule. Some patients prefer smaller doses more often, for example every day or every other day, and some find this feels more consistent. Results vary from person to person and are not guaranteed.

If you want to split your glutathione this way:

• Keep your weekly total at or below your prescription. Spread over more days, each dose gets smaller, but the total for the week stays the same or lower. Do not add extra.
• You will use your vial faster, so your supply may run out earlier than planned.
• Message your care team first so they can confirm the plan fits your prescription.

Taking glutathione with NAD+ or B12

There is no single best way to space them. Choose days that fit your routine. You do not need to stagger them in a particular order.

If you feel unusually weak or very fatigued after your injections, do not simply keep going. Message your care team and ask for a call with a provider before your next injection. If you ever have trouble breathing, swelling of the face, lips, tongue, or throat, or severe symptoms of any kind, call 911 or go to the ER.