Prescription only. For use under the supervision of a qualified healthcare provider.

BLACK BOX WARNING – Risk of Thyroid C-Cell Tumors

• Do not use Zepbound® if you or a family member has ever had:
  • Medullary thyroid carcinoma (MTC)
  • Multiple endocrine neoplasia syndrome type 2 (MEN 2)
• Zepbound® may cause tumors in the thyroid, including cancer.
• In animal studies, tirzepatide caused thyroid tumors; it is not known if it causes them in humans.
• Call your healthcare provider immediately if you notice a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.

Do Not Use Zepbound® If You Have:

• Type 1 diabetes
• Diabetic ketoacidosis
• Diabetic retinopathy
• Kidney disease
• Thyroid cancer
• Pancreatitis
• Multiple endocrine neoplasia syndrome type 2 (MEN 2)
• A serious allergic reaction to tirzepatide or any ingredient in Zepbound®

Before Using Zepbound®

Tell your healthcare provider if you have:

• Pancreas, kidney, or gallbladder problems
• Severe stomach problems (including gastroparesis or difficulty digesting food)
• A history of diabetic retinopathy
• Depression, suicidal thoughts, or other mental health changes
• Any other medical condition or allergies
  

Also tell your healthcare provider if you:

• Take diabetes medicines such as insulin or sulfonylureas (may increase risk of low blood sugar)
• Take birth control pills (effectiveness may decrease for 4 weeks after starting or increasing your Zepbound® dose; you may need an alternative form of contraception)
• Take any prescription, over-the-counter, or herbal medicines
• Are pregnant, planning to become pregnant, or breastfeeding (Zepbound® may harm your unborn baby; it is unknown if it passes into breast milk)
  

Pregnancy Exposure Registry: If you take Zepbound® while pregnant, you may be eligible to enroll in a registry that monitors health outcomes for you and your baby. Call Lilly at 1-800-LillyRx (1-800-545-5979).

Serious Warnings – Call Your Doctor Immediately If You Experience:

• Thyroid C-cell tumor symptoms (see Black Box Warning)
• Severe stomach problems: pain or discomfort that will not go away
• Pancreatitis: severe abdominal pain (with or without vomiting) that may radiate to your back
• Gallbladder disease: upper abdominal pain, fever, yellowing skin/eyes, clay-colored stools
• Kidney problems or kidney failure: especially if dehydrated from nausea, vomiting, or diarrhea
• Serious allergic reaction: swelling of face/lips/tongue/throat, difficulty breathing/swallowing, rash, itching, fainting, dizziness, or rapid heartbeat
• Low blood sugar: dizziness, sweating, confusion, blurred vision, slurred speech, shakiness, rapid heartbeat, hunger, irritability (especially if on insulin or sulfonylureas)
• Changes in vision (especially if you have type 2 diabetes)
• Depression or suicidal thoughts: changes in mood, behavior, or thoughts

Common Side Effects

Some people have no side effects. The most common include:

• Nausea, vomiting, diarrhea, constipation, abdominal pain
• Indigestion, acid reflux, belching, sour stomach
• Injection site reactions
• Fatigue
• Allergic reactions
• Hair loss
• Heartburn
• Gallbladder disease symptoms
• Low blood sugar (in people with type 2 diabetes on certain medications)
  

Side effects often lessen over time as your body adjusts. Contact your healthcare provider if they persist or worsen.

Other Safety Notes

• Zepbound® should be used with a reduced-calorie diet and increased physical activity.
• Do not use with other tirzepatide-containing products or any GLP-1 receptor agonists.
• Safety with other prescription, over-the-counter, or herbal weight-loss products is unknown.
• Zepbound® has not been studied in children under 18.
• Your healthcare provider should train you on proper injection technique before your first dose.

Emergency Information

• In a medical emergency, call 911 or go to the nearest emergency room.
• Report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.