If you’re considering Semaglutide (Ozempic®, Wegovy®) or Tirzepatide (Mounjaro®, Zepbound™) for weight loss, you’ve likely heard about the results—and the side effects.

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While these medications are incredibly effective, they can cause a range of symptoms as your body adjusts. The good news is that most side effects are temporary and manageable, especially when you’re prepared.

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In this guide, we’ll walk through the most common GLP-1 side effects, why they happen, and simple ways to feel better during your journey.

Why Side Effects Happen

Semaglutide and Tirzepatide work by mimicking natural gut hormones that slow digestion, reduce appetite, and regulate blood sugar. These powerful shifts can cause your body to react in new (and sometimes uncomfortable) ways, especially during the first 4–8 weeks.

Most Common GLP-1 Side Effects

1. Nausea

This is the most frequently reported side effect, especially when first starting or increasing your dose. It often improves as your body adapts.

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Tips to feel better:

• Eat smaller, slower meals
• Avoid greasy, fried, or heavy foods
• Stick to bland options like toast, rice, or broth-based soups
• Stay hydrated with electrolyte-rich fluids like HydroBelle hydration sticks

2. Constipation

Slowed digestion can lead to less frequent or more difficult bowel movements.

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Tips to feel better:

• Increase your fiber intake gradually (vegetables, chia seeds, oats)
• Drink at least 64 oz of water daily
• Try gentle movement, like walking after meals
• Consider magnesium or fiber supplements if approved by your provider

3. Fatigue

Some users report feeling tired, especially during the first few weeks. This can stem from reduced food intake, dehydration, or low blood sugar.

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Tips to feel better:

• Don’t skip meals—prioritize protein and balanced nutrition
• Stay hydrated, especially with electrolytes
• Supplement with NAD+ by Belle (coming soon!) for cellular energy support

4. Bloating or Gas

Because digestion slows, some people experience bloating or excess gas, especially after meals.

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Tips to feel better:

• Limit carbonated beverages and chewing gum
• Eat slowly and chew thoroughly
• Avoid trigger foods like beans, raw onions, or artificial sweeteners

5. Burping or Acid Reflux

Some experience an increase in reflux-like symptoms, especially with Tirzepatide.

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Tips to feel better:

• Avoid lying down after meals
• Reduce portion sizes
• Avoid caffeine, citrus, and spicy foods

6. Appetite Suppression

While this isn’t necessarily uncomfortable, it can lead to skipping meals or under-eating—both of which can worsen nausea or fatigue.

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Tips to feel better:

• Eat even when you’re not hungry—small, protein-rich meals are best
• Set reminders to eat regularly
• Keep easy snacks on hand like Greek yogurt, protein shakes, or hard-boiled eggs

When Do Side Effects Go Away?

For most people, side effects start to improve by weeks 3–6, especially if they are increasing their dose slowly and following basic nutrition and hydration guidance.

However, some people may continue to experience symptoms with each dose increase. If side effects are severe or persistent, talk to your provider. They may adjust your dose or recommend supportive care.

Stay Ahead of Side Effects with Supportive Tools

Two of the biggest reasons GLP-1 users struggle with side effects are dehydration and nutrient depletion. That’s why we recommend:

• HydroBelle hydration sticks — easy-to-use electrolyte support with no added sugar, designed to help reduce fatigue, headaches, and nausea
• NAD+ by Belle (coming soon!) — a daily supplement that supports cellular energy, mental clarity, and healthy aging

Together, these can help you feel more balanced, energized, and in control during your GLP-1 journey.

Ready to Feel Better on Your Weight Loss Journey?

At Belle, we offer more than just Semaglutide. We offer real support—medical guidance, lifestyle tips, and wellness tools to make sure you thrive, not just survive.

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Get started with Belle and shop HydroBelle to support your body, inside and out.

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